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The therapeutic effect of bupropion is presumed to bein partdue to the antidepressant activity of 3 metaboliteshydroxybupropionthreohydrobupropionand erythrohydrobupropion3 Using cells expressing human transporters for DANEand serotoninit has been shown in vitro that bupropiontogether with the active metabolitesinhibits both the NE and DA human transportersdata on fileGlaxoSmithKlineResearch Triangle ParkN.CInhibition of serotonin reuptake was negligible even at the highest concentrations tested.

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In clinical practicehypertensionin some cases severerequiring acute treatmenthas been reported in patients receiving bupropion alone and in combination with nicotine replacement therapyThese events have been observed in both patients with and without evidence of preexisting hypertension.

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