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6 mg one hour later; 152 wait 12 hours before resuming prophylactic doses of colchicine 152.

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Information about Colchicine.

Advise the patient to read the FDA-approved patient labelingMedication Guide

Colchicine is potentially toxic so it is important not to exceed the dose prescribed by a physician with the necessary knowledge and experience.

Colchicine is a substrate for both CYP3A4 and the transport protein P-gpIn the presence of CYP3A4 or P-gp inhibitorsthe concentrations of colchicine in the blood increaseToxicityincluding fatal caseshave been reported during concurrent use of CYP3A4 or P-gp inhibitors such as macrolidesclarithromycin and erythromycinciclosporinketoconazoleitraconazolevoriconazoleHIV protease inhibitorscalcium channel blockersverapamil and diltiazemand disulfiramsee section 4.4

Taking certain medicines with colchicine capsules can cause your level of colchicine to be too highespecially if you have kidney or liver problemsTell your healthcare provider about all your medical conditionsincluding if you have kidney or liver problemsYour dose of colchicine capsules may need to be changedEven medicines that you take for a short period of timesuch as antibioticscan interact with colchicine capsules and cause serious side effects or death.

Colchicine has been reported to cause neuromuscular toxicitywhich may present as muscle pain or weaknesssee WARNINGS AND PRECAUTIONS

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