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Depression is found among people who take compazine, especially for people who are female, 40-49 old , have been taking the drug for 1 month, also take medication zometa, and have multiple myeloma.

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The antiemetic benefits of prochlorperazine are due to dopamine blockade in the chemoreceptor trigger zone of the brainAdditionallyprochlorperazine has moderate effects on other neurotransmitters and receptorsBlockade of certain receptors called alpha-adrenergic receptors causes drowsinessmuscle relaxationand adverse cardiovascular effects such as low blood pressurereflex tachycardiaand changes in heart rhythm.

Low white blood cell countssudden weakness or ill feelingfeverchillssore throatswollen gumsmouth sorespain when swallowingskin sorescoughtrouble breathing;

Tell your doctor if you will be exposed to extreme heat or coldor to insecticide poisons while you are taking Compazine.

Some side effects of prochlorperazine may occur that usually do not need medical attentionThese side effects may go away during treatment as your body adjusts to the medicineAlsoyour health care professional may be able to tell you about ways to prevent or reduce some of these side effectsCheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Children seem more prone to develop extrapyramidal reactionseven on moderate dosesThereforeuse lowest effective dosageTell parents not to exceed prescribed dosagesince the possibility of adverse reactions increases as dosage rises.

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